Coenye Tom, Honraet Kris, Rigole Petra, Nadal Jimenez Pol, Nelis Hans J
Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium.
Antimicrob Agents Chemother. 2007 Apr;51(4):1541-4. doi: 10.1128/AAC.00999-06. Epub 2007 Jan 12.
We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by causing membrane perturbation.
我们报告称,某些蒽醌(AQs)在低于最低抑菌浓度(MIC)的浓度下可减少变形链球菌在羟基磷灰石上的生物膜形成。尽管已知AQs会产生活性氧,但后者并非观察到的效应的基础。我们的结果表明,AQs通过引起膜扰动来抑制变形链球菌生物膜的形成。