Fernandes Filho Sérgio Murilo Maciel, Costa Márcio Santos, Fernandes Mariana Torres, Foerster Miriam Vils
Setor de Emergência do Hospital Getúlio Vargas, Recife PE, Brasil (HGV).
Arq Neuropsiquiatr. 2006 Dec;64(4):1005-8. doi: 10.1590/s0004-282x2006000600023.
Migraine is one of the commonest diseases of clinical practice.
[corrected] To compare the analgesic effect of dipyrone to metoclopramide in the relief of pain.
We conducted a pilot randomized study comparing intravenous dipyrone to intravenous metoclopramide in 27 patients presenting acute crisis of migraine. The primary end point was to compare reduction of intensity of pain up to 2 hours, as well as the development of collateral effects.
The groups had similar ages, but there were difference between the sexes. In men, metoclopramide reduced pain in 80.0% compared with 55.0% from dipyrone (p=0.052). In women, there was a reduction of 65.0% with metoclopramide and 71.2% with dipyrone (p=0.748). The small number of patients in the study might have influenced these results. Significant collateral effects were not found.
There was no difference about the intensity of pain reduction neither about the development of collateral effects comparing dipyrone to metoclopramide.
偏头痛是临床实践中最常见的疾病之一。
比较安乃近与甲氧氯普胺在缓解疼痛方面的镇痛效果。
我们进行了一项前瞻性随机研究，对27例偏头痛急性发作患者静脉注射安乃近和静脉注射甲氧氯普胺进行比较。主要终点是比较2小时内疼痛强度的降低情况以及副作用的发生情况。
两组年龄相似，但性别存在差异。在男性中，甲氧氯普胺使80.0%的患者疼痛减轻，而安乃近为55.0%（p = 0.052）。在女性中，甲氧氯普胺使65.0%的患者疼痛减轻，安乃近为71.2%（p = 0.748）。研究中患者数量较少可能影响了这些结果。未发现明显的副作用。
比较安乃近与甲氧氯普胺，在减轻疼痛强度及副作用发生方面没有差异。
