[我们治疗外阴硬化性苔藓的经验]
[Our experience in treating vulvar lichen sclerosus].
作者信息
Cattani P, Manfrin E, Presti F, Sartori R, Buffo L
机构信息
Clinica Ostetrica e Ginecologica A, Università degli Studi, Verona.
出版信息
Minerva Ginecol. 1997 May;49(5):207-12.
METHODS
The authors looking for a better treatment of vulvar lichen sclerosus, treated 10 patients by topical application of clobetasol propionate (twice a day for 45 days and once a day for additional 45 days). Before and after therapy changes of subjective symptoms were studied with Vaona algometer as well as the histological modifications found in the biopsies of lesions like atrophy, hyperkeratosis, inflammatory infiltration, sclerosis, hyalinization and edema.
RESULTS
The results seem to confirm the good improvement of subjective symptoms for the itching and also for burning. The histological results were encouraging, in fact we noticed a marked reduction of inflammatory infiltration and an improvement of atrophy, hyperkeratosis, hyalinization and edema.
CONCLUSIONS
The clinical and histological results seem to confirm the therapeutic effect of the use of clobetasol propionate for the treatment of vulvar lichen sclerosus.
方法
为寻求对外阴硬化性苔藓更好的治疗方法，作者对10例患者外用丙酸氯倍他索进行治疗（每天2次，共45天，之后每天1次，再持续45天）。治疗前后，使用Vaona痛觉计研究主观症状的变化，并观察病变活检组织中的组织学改变，如萎缩、角化过度、炎症浸润、硬化、玻璃样变和水肿。
结果
结果似乎证实了主观症状（瘙痒和灼痛）有明显改善。组织学结果令人鼓舞，事实上我们注意到炎症浸润明显减少，萎缩、角化过度、玻璃样变和水肿有所改善。
结论
临床和组织学结果似乎证实了外用丙酸氯倍他索治疗外阴硬化性苔藓的疗效。
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