Fenelon G, Francois C, Percheron G, Yelnik J
Laboratoire de Neuromorphologie informationnelle et de Neurologie expérimentale du mouvement, Inserm Pavillon Claude Bernard, Hôpital de la Salpêtrière, Paris, France.
Neuroscience. 1991;45(2):495-510. doi: 10.1016/0306-4522(91)90244-i.
The distribution of the neurons of the central complex (or "centre médian-parafascicular complex") and of other thalamic regions projecting to the striatum was studied using a cartographic technique based on ventricular landmarks. The brain of a macaque was used as a reference for the cytoarchitectonic study of the complex. Three parts were isolated: the pars parafascicularis (or medial part), the pars media (or middle part) and the pars paralateralis (or lateral part). Wheat germ agglutinin conjugated to horseradish peroxidase was stereotaxically injected into either the sensorimotor or the associative territory of the striatum (i.e. the striatal space occupied by the axonal endings coming from either the sensorimotor or the associative cortex) of four macaques. Neurons projecting to the sensorimotor territory of the striatum were found to be located within the pars media (middle part) of the central complex while neurons projecting to the associative territory of the striatum were located within the pars parafascicularis. In all experimental cases, labelled neurons were scarce or absent in the pars paralateralis (or lateral part). Outside the central complex, neurons projecting to the sensorimotor territory of the striatum were scattered within the lateral part of the lateral mass, in the intralaminar nuclei and in the posterior part of the internal lamina. Neurons projecting to the associative territory of the striatum were observed mainly in the paraventricular region, dorsal to the rostral part of the lateral mass, and in the dorsolateral part of the nucleus oralis medialis. Our three-dimensional analysis of the clusters of the central complex cells projecting to the two striatal territories justifies the partitioning of the central complex into three parts. The pars media (or middle part), which projects to the sensorimotor territory of the striatum, receives selectively pallidal afferent axons. It belongs to the Nauta-Mehler loop, a closed loop linking the central complex to the basal ganglia. The pars parafascicularis, which projects to the associative territory of the striatum, seems more related to oculomotor neuronal systems. The pars paralateralis (or lateral part) appears to have very little, if any, relation with the striatum.
运用基于脑室标志的绘图技术，研究了中央复合体（或“中央中-束旁复合体”）及其他投射至纹状体的丘脑区域中神经元的分布情况。猕猴的大脑被用作该复合体细胞构筑学研究的参照。该复合体被分离为三个部分：束旁部（或内侧部）、中部和外侧部。将与辣根过氧化物酶结合的小麦胚芽凝集素立体定向注射到4只猕猴纹状体的感觉运动区或联合区（即分别由来自感觉运动皮层或联合皮层的轴突终末所占据的纹状体空间）。结果发现，投射至纹状体感觉运动区的神经元位于中央复合体的中部，而投射至纹状体联合区的神经元位于束旁部。在所有实验案例中，外侧部的标记神经元稀少或缺失。在中央复合体之外，投射至纹状体感觉运动区的神经元散布于外侧核团的外侧部、板内核以及内板后部。投射至纹状体联合区的神经元主要见于室旁区域，即外侧核团嘴侧部的背侧，以及内侧口核的背外侧部。我们对投射至两个纹状体区域的中央复合体细胞簇进行的三维分析，证实了可将中央复合体划分为三个部分。投射至纹状体感觉运动区的中部选择性地接受苍白球传入轴突。它属于瑙塔-梅勒环路，这是一个将中央复合体与基底神经节相连的闭环。投射至纹状体联合区的束旁部似乎与动眼神经神经元系统关系更为密切。外侧部与纹状体的关系似乎微乎其微（若有也极为有限）。
