Tatton W G, Greenwood C E, Salo P T, Seniuk N A
Department of Physiology, University of Toronto, Ont, Canada.
Neurosci Lett. 1991 Oct 14;131(2):179-82. doi: 10.1016/0304-3940(91)90608-v.
Striatal dopamine concentrations are relatively well maintained with age despite extensive death of the nigrostriatal neurons whose terminals contain the dopamine. Counts of nigrostriatal dopaminergic neurons in C57BL mice identified using immunocytochemistry, Fluoro-Gold retrograde axonal transport and Nissl staining were combined with measures of striatal dopamine and DOPA after saline, pargyline or NSD-1015 treatment. On average, 68% of the dopaminergic nigrostriatal neurons died between ages 8 and 104 weeks and there was a 3-fold increase in dopamine synthesis per average neuron in the aged mice. Increased transmitter synthesis by surviving neurons may serve to compensate brain function in old age.
尽管黑质纹状体神经元大量死亡，但其终末含有多巴胺，纹状体多巴胺浓度随年龄增长相对保持良好。使用免疫细胞化学、荧光金逆行轴突运输和尼氏染色鉴定的C57BL小鼠黑质纹状体多巴胺能神经元计数，与生理盐水、帕吉林或NSD - 1015处理后纹状体多巴胺和多巴的测量结果相结合。平均而言，68%的多巴胺能黑质纹状体神经元在8至104周龄之间死亡，老年小鼠中每个平均神经元的多巴胺合成增加了3倍。存活神经元中递质合成的增加可能有助于补偿老年时的脑功能。
