(1S,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin ([+]-AJ-76) elevates transmitter synthesis in dopaminergic neurons surviving a partial nigrostriatal lesion.

(+)-AJ-76 is a novel compound with a spectrum of actions suggesting that it is a selective antagonist of dopamine (DA) autoreceptors. In animals with partial lesions of the dopaminergic nigrostriatal system, in which DA synthesis of surviving neurons was elevated, (+)-AJ-76 further increased DA synthesis above levels produced by the lesion alone. This finding suggests that (+)-AJ-76 might be of value in the treatment of Parkinson's disease.