Cameron A A, Cliffer K D, Dougherty P M, Willis W D, Carlton S M
Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77550.
Neurosci Lett. 1991 Oct 14;131(2):249-52. doi: 10.1016/0304-3940(91)90625-4.
The density and distribution of reactivity for two lectins (soybean agglutinin (SBA) and RL-29), growth associated protein-43 (GAP-43) and the neuropeptides substance P and calcitonin gene-related peptide were analyzed in the spinal cord dorsal horn of rats with an experimental peripheral neuropathy. Twenty-eight days postsurgery, the density of label for RL-29 and GAP-43 was increased in laminae I and II on the experimental compared to the control side. In contrast, the density of neuropeptide label was decreased in the same region. Furthermore, on the experimental side, the distribution of both SBA and RL-29 reactivity was increased, extending into lamina III. We hypothesize that the increases in density and distribution of reactivity for the lectins and GAP-43, as well as the decreases in neuropeptide reactivity, reflect injury-induced regenerative changes in primary afferent terminals.
对患有实验性周围神经病变大鼠的脊髓背角中两种凝集素（大豆凝集素（SBA）和RL - 29）、生长相关蛋白43（GAP - 43）以及神经肽P物质和降钙素基因相关肽的反应性密度和分布进行了分析。术后28天，与对照侧相比，实验侧I层和II层中RL - 29和GAP - 43的标记密度增加。相反，同一区域的神经肽标记密度降低。此外，在实验侧，SBA和RL - 29反应性的分布均增加，延伸至III层。我们推测，凝集素和GAP - 43反应性密度和分布的增加以及神经肽反应性的降低反映了初级传入终末损伤诱导的再生变化。
