Appelgren A, Appelgren B, Eriksson S, Kopp S, Lundeberg T, Nylander M, Theodorsson E
Department of Clinical Oral Physiology, Karolinska Institutet, Huddinge, Sweden.
Scand J Dent Res. 1991 Dec;99(6):519-21. doi: 10.1111/j.1600-0722.1991.tb01063.x.
There is evidence that neuropeptides play a role in the development of arthritis. Synovial fluid from arthritic temporomandibular joints in patients with rheumatoid arthritis was therefore investigated for presence of the neuropeptides calcitonin gene-related peptide, substance P, neurokinin A and neuropeptide Y. All four peptides were found in the synovial fluid above plasma level, but calcitonin gene-related peptide showed the highest concentration and substance P the lowest.
