Heller Jörg, Sauerbruch Tilman
Department of Internal Medicine I, University of Bonn, Sigmund-Freud Strasse 25, D-53105 Bonn, Germany.
Best Pract Res Clin Gastroenterol. 2007;21(1):43-53. doi: 10.1016/j.bpg.2006.07.003.
Patients who survive a first bleeding episode of oesophageal varices have a high risk of rebleeding, which is associated with a high mortality rate. Prevention of a recurrent haemorrhage is therefore recommended. Patients who were not on a primary prophylaxis should be treated with non-selective beta-adrenoceptor antagonists, endoscopic band ligation or both. If beta-blockers are not tolerated or are contraindicated, patients should be treated with endoscopic band ligation. If these preventive strategies fail, transjugular intrahepatic portosystemic shunt (covered) or a small-diameter surgical shunt is indicated.
食管静脉曲张首次出血发作后存活的患者有很高的再出血风险,这与高死亡率相关。因此,建议预防复发性出血。未进行一级预防的患者应使用非选择性β肾上腺素能受体拮抗剂、内镜下套扎术或两者联合治疗。如果不能耐受β受体阻滞剂或有禁忌证,患者应接受内镜下套扎术治疗。如果这些预防策略失败,则应采用经颈静脉肝内门体分流术(覆膜)或小直径外科分流术。