Menger Dirk-Jan, Fokkens Wytske J, Lohuis Peter J F M, Ingels Koen J, Nolst Trenité Gilbert J
Department of Otorhinolaryngology/Head and Neck Surgery, Center for Facial Plastic and Reconstructive Surgery, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
J Plast Reconstr Aesthet Surg. 2007;60(2):152-62. doi: 10.1016/j.bjps.2006.06.015. Epub 2006 Sep 14.
There has still been no reduction in the detection rate worldwide for leprosy, despite supervised multi-drug therapy. In time, leprosy can result in a severe saddle-nose deformity leading to functional problems, disfiguration and stigmatization. In severe cases, only the nasal skin tissue and the lower lateral cartilages are preserved. In such cases, the ideal would be to restore the cartilaginous skeleton but, by contrast with other causes of saddle-nose deformities, this is complicated by the quantity and the poor quality of the remaining nasal mucosa. Leprosy-related saddle-nose deformities are therefore challenging and difficult to reconstruct with the techniques that have been proposed in the past. In this study, 24 patients underwent rhinoplastic surgery involving the use of autogenous costal and/or auricular cartilage or composite grafts. The nasal septum, the upper laterals and the anterior nasal spine were reconstructed with a dorsal onlay attached to a columellar strut with an extension on the proximal side. Before surgery, the saddle-nose deformities were classified according to severity with a new system based on clinical symptoms and signs. Postoperative evaluation was performed at least two years after surgery (N=17). Functional and aesthetic improvement, resorption rate, warping, infection and extrusion were analysed. Functional and aesthetic improvements were achieved in 15/17 patients. None of the patients developed an infection and extrusion or warping of the implants was not observed. The resorption rate depended on the localization and the type of cartilage implant. In general, auricular conchal cartilage implant grafts resulted in less resorption than costal cartilage. Least resorption (4/17 patients) was observed in the dorsal onlay grafts of both conchal (1/6) and costal cartilage grafts (3/11). Resorption of columellar strut implants and shield grafts was observed in 7/17 patients. No resorption was seen of composite grafts (0/4) and alar battens (0/7). Autogenous cartilage implants can be used to reconstruct saddle-nose deformities in leprosy with a minimum risk of complications. The preoperative grade of severity was used as a basis for the development of guidelines for optimal long-term functional and aesthetic outcome.
尽管采用了监督下的多药联合疗法,但全球范围内麻风病的检出率仍未降低。随着时间的推移,麻风病会导致严重的鞍鼻畸形,进而引发功能问题、容貌毁损和污名化。在严重病例中,仅保留鼻皮肤组织和下外侧软骨。在这种情况下,理想的做法是恢复软骨支架,但与鞍鼻畸形的其他病因不同,剩余鼻黏膜的数量和质量较差使这一过程变得复杂。因此,与麻风病相关的鞍鼻畸形具有挑战性,难以用过去提出的技术进行重建。在本研究中,24例患者接受了鼻整形手术,采用了自体肋软骨和/或耳软骨或复合移植物。鼻中隔、上外侧软骨和前鼻棘通过附着在鼻小柱支柱上的背侧嵌体进行重建,近端有延伸。术前,根据基于临床症状和体征的新系统对鞍鼻畸形的严重程度进行分类。术后评估在术后至少两年进行(N = 17)。分析了功能和美学改善、吸收率、翘曲、感染和排斥情况。17例患者中有15例实现了功能和美学改善。没有患者发生感染,也未观察到植入物的排斥或翘曲。吸收率取决于软骨植入物的位置和类型。一般来说,耳甲软骨植入移植物的吸收率低于肋软骨。在耳甲软骨(1/6)和肋软骨移植物(3/11)的背侧嵌体移植物中观察到的吸收率最低(4/17例患者)。17例患者中有7例观察到鼻小柱支柱植入物和盾牌移植物的吸收。复合移植物(0/4)和鼻翼支撑条(0/7)未观察到吸收。自体软骨植入物可用于重建麻风病患者的鞍鼻畸形,并发症风险最小。术前严重程度分级被用作制定最佳长期功能和美学结果指南的基础。