Mullins G M, O'sullivan S S, Neligan A, McCarthy A, McNamara B, Galvin R J, Sweeney B J
Department of Neurology and Neurophysiology, Cork University Hospital, Cork, Ireland.
Seizure. 2007 Apr;16(3):204-10. doi: 10.1016/j.seizure.2006.12.007. Epub 2007 Jan 12.
Idiopathic generalised epilepsy (IGE) is subdivided into syndromes based on clinical and EEG features.
The aim of this study was to characterise all cases of IGE with supportive EEG abnormalities in terms of gender differences, seizure types reported, IGE syndromes, family history of epilepsy and EEG findings. We also calculated the limited duration prevalence of IGE in our cohort.
Data on abnormal EEGs were collected retrospectively from two EEG databases at two tertiary referral centres for neurology. Clinical information was obtained from EEG request forms, standardised EEG questionnaires and medical notes of patients.
two hundred twenty-three patients met our inclusion criteria, 89 (39.9%) male and 134 (60.1%) females. Tonic clonic seizures were the most common seizure type reported, 162 (72.65%) having a generalised tonic clonic seizure (GTCS) at some time. IGE with GTCS only (EGTCSA) was the most common syndrome in our cohort being present in 94 patients (34 male, 60 female), with 42 (15 male, 27 female) patients diagnosed with Juvenile myoclonic epilepsy (JME), 23 (9 male, 14 female) with Juvenile absence epilepsy (JAE) and 20 (9 male, 11 female) with childhood absence epilepsy (CAE). EEG studies in all patients showed generalised epileptiform activity.
More women than men were diagnosed with generalised epilepsy. Tonic clonic seizures were the most common seizure type reported. EGTCSA was the most frequent syndrome seen. Gender differences were evident for JAE and JME as previously reported and for EGTCSA, which was not reported to date, and reached statistical significance for EGTCA and JME.
特发性全身性癫痫（IGE）根据临床和脑电图特征细分为不同综合征。
本研究的目的是根据性别差异、报告的发作类型、IGE综合征、癫痫家族史和脑电图结果，对所有伴有支持性脑电图异常的IGE病例进行特征描述。我们还计算了队列中IGE的有限病程患病率。
从两个三级神经科转诊中心的脑电图数据库中回顾性收集脑电图异常数据。临床信息从脑电图申请表、标准化脑电图问卷和患者病历中获取。
223名患者符合我们的纳入标准，其中男性89名（39.9%），女性134名（60.1%）。强直阵挛发作是报告中最常见的发作类型，162名（72.65%）患者在某个时间出现全身性强直阵挛发作（GTCS）。仅伴有GTCS的IGE（EGTCSA）是我们队列中最常见的综合征，94名患者（男性34名，女性60名）出现该综合征，42名（男性15名，女性27名）患者被诊断为青少年肌阵挛癫痫（JME），23名（男性9名，女性14名）患有青少年失神癫痫（JAE），20名（男性9名，女性11名）患有儿童失神癫痫（CAE）。所有患者的脑电图研究均显示全身性癫痫样活动。
被诊断为全身性癫痫的女性多于男性。强直阵挛发作是报告中最常见的发作类型。EGTCSA是最常出现的综合征。如先前报道，JAE和JME存在性别差异，EGTCSA此前未被报道，EGTCA和JME的性别差异具有统计学意义。
