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[大鼠脑内胚胎杏仁核与视觉皮层移植植入情况的比较及功能障碍可能的补偿作用]

[A comparison of the take of embryonic amygdala and visual cortex transplants in the rat brain in connection with the possible compensation of functional disorders].

作者信息

Lushchekina E A, Lushchekin V S, Khonicheva N M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 Sep-Oct;41(5):1059-69.

PMID:1722372
Abstract

Transplantation of embryonic (E17-18) visual cortex and amygdala was performed into corresponding damaged areas of the adult rat brain. It was shown in Nissl and Golgi preparations (by comparing qualitative and quantitative findings) that 2-6 months after operation the grafts were successful in case of putting them into the corresponding brain areas (cortex to cortex, or amygdala to amygdala). Graft's integration resulted in a selective increase of dendrite length and ramification towards the area of graft-host interface both in amygdala and visual cortex grafts. In case of inadequate graft-host integration the stratification of the grafted visual cortex could be observed. The structural reorganization of grafted neurones is compared with physiological and behavioural findings during the recovery processes in damaged brain.

摘要

将胚胎(E17 - 18)期的视觉皮层和杏仁核移植到成年大鼠大脑相应的受损区域。在尼氏染色和高尔基染色标本中(通过比较定性和定量结果)显示,术后2 - 6个月,将移植物植入相应脑区(皮层对皮层,或杏仁核对杏仁核)时移植成功。移植物的整合导致杏仁核和视觉皮层移植物中,朝向移植物 - 宿主界面区域的树突长度和分支选择性增加。在移植物与宿主整合不充分的情况下,可以观察到移植的视觉皮层分层现象。将移植神经元的结构重组与受损大脑恢复过程中的生理和行为结果进行了比较。

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