Lavagnino L, Cao B, Mwangi B, Wu M-J, Sanches M, Zunta-Soares G B, Kapczinski F, Soares J
Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, UT Center of Excellence on Mood Disorders, Houston, TX, USA.
Acta Psychiatr Scand. 2015 Jun;131(6):458-64. doi: 10.1111/acps.12397. Epub 2015 Jan 31.
This study investigated the differences in corpus callosum (CC) volumes between women with early-stage and late-stage bipolar I (BP I) disorder using the criteria previously described in the literature.
We compared women with early- and late-stage BP I using criteria described in the Staging Systems Task Force Report of the International Society for Bipolar Disorders. We included 20 patients with early stage and 21 patients with late-stage BP I and a group of 25 healthy controls. Patients and controls underwent structural magnetic resonance imaging. Information on the clinical features of bipolar disorder was collected using a standardized questionnaire. Anatomical volumes of five regions of CC were compared between the three groups.
Women with late-stage BP I disorder had reduced posterior CC volumes compared with early-stage bipolar I patients and controls (F = 6.05; P = 0.004). The difference was significant after controlling for age, comorbidity with post-traumatic stress disorder, psychotic symptoms during mood episodes, and current use of medication.
The posterior CC was significantly decreased in volume in women with late-stage bipolar disorder. These findings suggest that CC may be an anatomical target of neuroprogression in the course of bipolar disorder in women.
本研究采用文献中先前描述的标准，调查了早期和晚期双相I型（BP I）障碍女性胼胝体（CC）体积的差异。
我们使用国际双相障碍协会分期系统工作组报告中描述的标准，比较了早期和晚期BP I女性。我们纳入了20例早期BP I患者、21例晚期BP I患者以及一组25名健康对照者。患者和对照者均接受了结构磁共振成像检查。使用标准化问卷收集双相障碍的临床特征信息。比较了三组之间CC五个区域的解剖体积。
与早期双相I型患者和对照者相比，晚期BP I障碍女性的CC后部体积减小（F = 6.05；P = 0.004）。在控制年龄、创伤后应激障碍共病、情绪发作期间的精神病症状以及当前用药情况后，差异具有统计学意义。
晚期双相障碍女性的CC后部体积显著减小。这些发现表明，CC可能是女性双相障碍病程中神经进展的一个解剖学靶点。
