Pretorius A, Collins N E, Steyn H C, van Strijp F, van Kleef M, Allsopp B A
Onderstepoort Veterinary Institute, Private Bag X5, Onderstepoort 0110, South Africa.
Vaccine. 2007 Mar 8;25(12):2316-24. doi: 10.1016/j.vaccine.2006.11.061. Epub 2006 Dec 11.
We have reported previously that a recombinant DNA vaccine consisting of four Ehrlichia ruminantium (Welgevonden) open reading frames (ORFs) known as the 1H12 cocktail provided protection against a virulent E. ruminantium (Welgevonden) needle challenge in sheep. In this study, we have investigated the vaccine effectiveness of two other cocktails of E. ruminantium (Welgevonden) ORFs, as well as single ORFs from the 1H12 cocktail, to protect sheep against a virulent needle challenge with the homologous strain. Each individual 1H12 ORF provided protection, but all the animals vaccinated with the other cocktails succumbed to the challenge.
我们之前报道过，一种由四个反刍兽埃立克体（韦尔格芬登株）开放阅读框（ORF）组成的重组DNA疫苗，即1H12混合疫苗，可保护绵羊免受强毒反刍兽埃立克体（韦尔格芬登株）针刺攻击。在本研究中，我们调查了另外两种反刍兽埃立克体（韦尔格芬登株）ORF混合疫苗以及1H12混合疫苗中的单个ORF对绵羊抵御同源强毒株针刺攻击的疫苗效力。1H12混合疫苗中的每个单独ORF都提供了保护，但接种其他混合疫苗的所有动物都在攻击中死亡。
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