减毒反刍兽艾里希体（韦尔格芬登株）疫苗在美利奴绵羊和安哥拉山羊中的实验性应用。

Experimental use of the attenuated Ehrlichia ruminantium (Welgevonden) vaccine in Merino sheep and Angora goats.

作者信息

Zweygarth Erich, Josemans Antoinette I, Steyn Helena C

机构信息

Onderstepoort Veterinary Institute, Onderstepoort 0110, South Africa.

出版信息

Vaccine. 2008 Dec 19;26 Suppl 6:G34-9. doi: 10.1016/j.vaccine.2008.09.068.

DOI:10.1016/j.vaccine.2008.09.068

PMID:19178891

Abstract

The attenuated Ehrlichia ruminantium (Welgevonden) stock provides protection against a virulent homologous needle challenge in Merino sheep and Boer goats against heartwater. In this study, cryopreserved stabilates were tested for their suitability as a vaccine in Merino sheep. Vaccination did not produce disease and upon challenge with the virulent homologous stock all animals were fully protected. The vaccination protected all except one animal out of 5 challenged 12 months after immunization. The intramuscular route gave better protection than the subcutaneously applied vaccine. The attenuated vaccine was further evaluated in highly susceptible Angora goats. Although the attenuated vaccine showed an unexpectedly high degree of virulence, animals were fully protected against a lethal needle challenge.

摘要

减毒的反刍兽埃立克体（韦尔格冯登毒株）毒株可保护美利奴绵羊和布尔山羊抵御同源强毒株针接种引发的心水病。在本研究中，对冷冻保存的冻干菌苗进行了测试，以评估其作为美利奴绵羊疫苗的适用性。接种疫苗未引发疾病，在用同源强毒株攻击后，所有动物均得到充分保护。免疫12个月后，5只接受攻击的动物中，除1只外全部受到疫苗保护。肌内接种途径比皮下接种疫苗提供了更好的保护。在高度易感的安哥拉山羊中对减毒疫苗进行了进一步评估。尽管减毒疫苗显示出出乎意料的高毒力，但动物在接受致死性针接种攻击后均得到充分保护。