25G玻璃体切除术治疗家族性淀粉样多神经病的眼部并发症。
25-gauge vitrectomy to treat ocular complications of familial amyloid polyneuropathy.
作者信息
Miyahara Teruyoshi, Ohta Kouichi, Yamamoto Yuka, Ueno Azumi, Murata Toshinori
机构信息
Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
出版信息
J Glaucoma. 2007 Jan;16(1):169-70. doi: 10.1097/01.ijg.0000212291.85669.21.
PURPOSE
Secondary glaucoma and vitreous opacity with amyloid fibrils are the 2 major ocular complications of familial amyloid polyneuropathy (FAP). We investigated the feasibility of 25-gauge vitrectomy in excising the opaque vitreous into eyes that had already undergone trabeculectomy.
METHODS
For the purpose of vision recovery, 25-gauge vitrectomy was performed in 2 eyes with vitreous amyloidosis. Both eyes had undergone trabeculectomy to treat glaucoma secondary to FAP. The survival of the filtration bleb after 25-gauge vitrectomy was also evaluated.
RESULTS
Vision improved dramatically on the next day after the 25-gauge vitrectomy that causes minimal damage to the eye. No apparent complications including failure of the filtration bleb have been observed throughout the follow-up period of 6 months.
CONCLUSIONS
25-gauge vitrectomy has a potential to become a therapy of choice to excise opaque vitreous with amyloid fibrils in FAP, especially in the glaucomatous eyes that have already undergone trabeculectomy.
目的
继发性青光眼和伴有淀粉样原纤维的玻璃体混浊是家族性淀粉样多神经病（FAP）的两大主要眼部并发症。我们研究了25G玻璃体切除术切除已接受小梁切除术的眼中不透明玻璃体的可行性。
方法
为恢复视力，对2例玻璃体淀粉样变性患者的眼睛进行了25G玻璃体切除术。这两只眼睛均已接受小梁切除术以治疗FAP继发的青光眼。同时评估了25G玻璃体切除术后滤过泡的存活情况。
结果
25G玻璃体切除术对眼睛造成的损伤极小，术后第二天视力显著改善。在6个月的随访期内未观察到明显并发症，包括滤过泡失败。
结论
25G玻璃体切除术有可能成为切除FAP中伴有淀粉样原纤维的不透明玻璃体的首选治疗方法，尤其是对于已经接受小梁切除术的青光眼患者。
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