Leiter Lawrence A
Division of Endocrinology and Metabolism, St. Michael's Hospital and Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Rev Cardiovasc Med. 2006;7 Suppl 2:S3-9.
Blood glucose is a continuous, progressive risk factor for cardiovascular disease (CVD) throughout the dysglycemic range. There is also evidence that post-prandial hyperglycemia may be a better predictor of CVD risk than fasting plasma glucose or A1C. Targeting normoglycemia appears to reduce CVD events in diabetes mellitus (DM), although definitive studies in type 2 DM, as well as in prediabetes, are ongoing. Prediabetes has some, but not total, overlaps with the metabolic syndrome. Patients with the metabolic syndrome are at a significantly increased risk for both CVD and DM. Although the individual components of the syndrome predict risk for CVD to approximately equal degree, increased blood glucose, perhaps not surprisingly, is the best predictor of diabetes. Finally, there are multiple mechanisms by which hyperglycemia can increase the risk for CVD.
在整个血糖异常范围内，血糖是心血管疾病（CVD）持续、渐进的危险因素。也有证据表明，餐后高血糖可能比空腹血糖或糖化血红蛋白（A1C）更能预测心血管疾病风险。尽管针对2型糖尿病以及糖尿病前期的确定性研究仍在进行，但将血糖控制在正常水平似乎可以减少糖尿病（DM）患者的心血管疾病事件。糖尿病前期与代谢综合征有部分重叠，但并非完全重叠。患有代谢综合征的患者患心血管疾病和糖尿病的风险显著增加。虽然该综合征的各个组成部分对心血管疾病风险的预测程度大致相同，但血糖升高可能并不意外地是糖尿病的最佳预测指标。最后，高血糖可通过多种机制增加心血管疾病风险。
