非甾体抗炎药所致胃病及上腹部症状的预防

The prevention of gastropathy and upper abdominal symptoms caused by nonsteroidal anti-inflammatory drugs.

作者信息

Vakil Nimish

机构信息

University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

出版信息

Rev Gastroenterol Disord. 2006 Fall;6(4):221-6.

PMID:17224894

Abstract

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is increasing, primarily due to arthritis in the aging population. This article reviews current data on the risk of gastrointestinal complications related to NSAIDs and strategies to manage risk in patients taking these agents. Risks of NSAID use include gastrointestinal ulceration, hemorrhage, or perforation; renal dysfunction; death; and dyspepsia. Alternate therapies include use of non-NSAID analgesics; low-dose NSAIDs; and concurrent administration of cytoprotective agents with NSAIDs, acid inhibitors, proton pump inhibitors, and COX-2 agents.

摘要

非甾体抗炎药（NSAIDs）的使用正在增加，主要原因是老年人群中的关节炎。本文综述了目前关于NSAIDs相关胃肠道并发症风险的数据，以及管理服用这些药物患者风险的策略。使用NSAIDs的风险包括胃肠道溃疡、出血或穿孔；肾功能不全；死亡；以及消化不良。替代疗法包括使用非NSAID类镇痛药；低剂量NSAIDs；以及将细胞保护剂与NSAIDs、酸抑制剂、质子泵抑制剂和COX-2抑制剂联合使用。