Hastings G Z, Rowlands D J, Francis M J
Wellcome Biotech, Langley Court, Beckenham, Kent, U.K.
J Gen Virol. 1991 Dec;72 ( Pt 12):2947-52. doi: 10.1099/0022-1317-72-12-2947.
Lymphocytes from mice immunized with human rhinovirus (HRV) serotypes 1A or 15 proliferated in vitro in response to HRV and the activated cells were shown to be helper T (Th) cells. Lymphocytes from mice primed with HRV-1A responded to seven of eight heterologous virus serotypes, the responses to other minor cell receptor group viruses being greater than to those belonging to the major cell receptor group. A similar bias was seen with cells from mice primed with HRV-15 in that they responded preferentially to other major receptor group viruses. This pattern of cross-serotype recognition was shown to be similar in three inbred mouse strains and was not dependent upon the major histocompatibility complex haplotype. These results have revealed that there are determinants within the viral proteins of a number of serotypes of HRV that are recognized by Th cells primed against a single HRV serotype. Thus, at the level of Th cell recognition of HRV, a cross-serotype reactivity is seen which is not reflected in the B cell antibody response to virus, which is generally highly serotype-specific.
用1A或15型人鼻病毒（HRV）免疫的小鼠淋巴细胞，在体外对HRV产生增殖反应，且活化细胞显示为辅助性T（Th）细胞。用HRV-1A免疫的小鼠淋巴细胞对8种异源病毒血清型中的7种产生反应，对其他次要细胞受体组病毒的反应大于对主要细胞受体组病毒的反应。在用HRV-15免疫的小鼠细胞中也观察到类似的偏向性，即它们优先对其他主要受体组病毒产生反应。这种交叉血清型识别模式在三种近交系小鼠品系中显示相似，且不依赖于主要组织相容性复合体单倍型。这些结果表明，多种HRV血清型的病毒蛋白中存在一些决定簇，可被针对单一HRV血清型致敏的Th细胞识别。因此，在Th细胞对HRV的识别水平上，可观察到一种交叉血清型反应性，而这种反应性在B细胞对病毒的抗体反应中并未体现，B细胞抗体反应通常具有高度血清型特异性。
