Trabuco Emanuel C, Klingele Christopher J, Gebhart John B
Division of Gynecologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Int Urogynecol J Pelvic Floor Dysfunct. 2007 May;18(5):555-63. doi: 10.1007/s00192-006-0288-2. Epub 2007 Jan 17.
Xenografts, bovine or porcine acellular collagen bioprostheses derived from dermis, pericardium, or small-intestine submucosa, were introduced to overcome synthetic mesh-related complications. Although there are eight commercially available xenografts, there is a paucity of empiric information to justify their use instead of the use of synthetic grafts. In addition, limited data are available about which graft characteristics are important and whether graft-reinforced repairs reduce recurrences and improve outcomes. To address these knowledge gaps, we conducted a Medline search of published reports on xenografts in animal and human trials. Histologic host response to implanted xenograft material depends primarily on chemical cross-linking and porosity, and it is limited to four responses: resorption, incorporation, encapsulation, and mixed. No clinical data unequivocally demonstrate an improved benefit to graft-reinforced repair.
异种移植物，即源自真皮、心包或小肠黏膜下层的牛或猪脱细胞胶原生物假体，被引入以克服与合成补片相关的并发症。尽管有八种市售的异种移植物，但缺乏经验性信息来证明使用它们而非合成移植物的合理性。此外，关于哪些移植物特性很重要以及移植物强化修复是否能减少复发并改善预后的数据有限。为了填补这些知识空白，我们对动物和人体试验中关于异种移植物的已发表报告进行了医学文献数据库检索。组织学上宿主对植入异种移植物材料的反应主要取决于化学交联和孔隙率，并且仅限于四种反应：吸收、整合、包裹和混合。没有临床数据明确证明移植物强化修复有更好的益处。
