Warrington R C, Fang W D
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
Anticancer Res. 1991 Sep-Oct;11(5):1869-74.
An artificial hematogenous-metastasis model, in which B16f10 melanoma cells injected into the tail veins of C57/BL mice arrest in the lungs and proliferate as discrete pulmonary foci, was employed to examine effects of L-histidinol on the capacity of a number of conventional antineoplastic agents to manage disseminated disease. Treatment responses were evaluated by determining both the number of lung foci and/or by evaluating animal survival. L-Histidinol, on its own, was found to have a significant and dose-dependent capacity to reduce the number of lung foci and to extend survival of animals bearing disseminated B16f10 melanoma. L-Histidinol enhanced the ability of bis-chloroethylnitrosourea, 5-fluorouracil, and 1-beta-D-arabinofuranosulcytosine to reduce the number of lung foci. The latter combinations also gave marked improvements in survival, whether administered 1 or 7 days after the intravenous injection of tumor cells.
采用一种人工血行转移模型，即将B16f10黑色素瘤细胞注入C57/BL小鼠尾静脉，使其在肺部滞留并增殖形成离散的肺转移灶，来研究L-组氨醇对多种传统抗肿瘤药物治疗播散性疾病能力的影响。通过确定肺转移灶数量和/或评估动物存活率来评价治疗反应。结果发现，L-组氨醇自身具有显著的剂量依赖性能力，可减少肺转移灶数量并延长荷播散性B16f10黑色素瘤动物的存活期。L-组氨醇增强了双氯乙基亚硝脲、5-氟尿嘧啶和1-β-D-阿拉伯呋喃糖基胞嘧啶减少肺转移灶数量的能力。无论在静脉注射肿瘤细胞后1天还是7天给予上述联合用药，动物存活率均有显著提高。
