Warrington R C, Fang W D
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
Anticancer Res. 1991 Sep-Oct;11(5):1879-83.
A comparison of the effects of L-histidinol and homoharringtonine (HHT) on the activity of 5-fluorouracil (FUra) and bis-chloroehtylnitrosourea (BCNU) in C57/BL mice, without or with disseminated B16f10 melanoma, was carried out. Although L-histidinol and HHT are both protein synthesis inhibitors with apparently identical modes of action, these two compounds had very different effects in the test systems. HHT failed to prevent the body weight lose and subsequent death of C57/BL mice treated with supralethal doses of FUra; it was also unable to prevent the toxicity of FUra for bone marrow cells. In contrast, L-histidinol prevented the weight loss, death and bone marrow damage otherwise resulting from identical doses of FUra. Furthermore, L-histidinol was far more effective than HHT in its ability to improve the management of disseminated B16f10 melanoma in C57/BL mice by BCNU, both in terms of reducing pulmonary foci and extending survival.
在有无播散性B16f10黑色素瘤的C57/BL小鼠中，对L-组氨醇和高三尖杉酯碱（HHT）对5-氟尿嘧啶（FUra）和双氯乙基亚硝脲（BCNU）活性的影响进行了比较。尽管L-组氨醇和HHT都是蛋白质合成抑制剂，作用方式明显相同，但这两种化合物在测试系统中的效果却大不相同。HHT无法防止接受超致死剂量FUra治疗的C57/BL小鼠体重减轻和随后的死亡；它也无法防止FUra对骨髓细胞的毒性。相比之下，L-组氨醇可防止相同剂量FUra导致的体重减轻、死亡和骨髓损伤。此外，就减少肺转移灶和延长生存期而言，L-组氨醇在改善BCNU对C57/BL小鼠播散性B16f10黑色素瘤的治疗效果方面比HHT有效得多。
