Aggarwal Neelum T, Decarli Charles
Rush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.
Semin Neurol. 2007 Feb;27(1):66-77. doi: 10.1055/s-2006-956757.
Vascular dementia is a term used to describe a constellation of cognitive and functional impairment that can be viewed as a subset of the larger syndrome of vascular cognitive impairment associated with cerebrovascular brain injury. Vascular dementia is a common disorder among the elderly, although it can also occur in younger persons. Comprising 20% of all cases of dementia in the United States, vascular dementia is the second most common form of dementia after Alzheimer's disease. Patients with vascular dementia often exhibit mood and behavioral changes and may have focal neurological signs on neurological examination. Primary treatment is through primary or secondary modification of cerebrovascular risk factors such as hypertension, although symptomatic treatments with cholinesterase inhibitors have shown modest symptomatic benefit.
血管性痴呆是一个术语，用于描述一系列认知和功能障碍，可被视为与脑血管脑损伤相关的更大的血管性认知障碍综合征的一个子集。血管性痴呆在老年人中是一种常见疾病，尽管它也可能发生在年轻人身上。在美国，血管性痴呆占所有痴呆病例的20%，是仅次于阿尔茨海默病的第二常见痴呆形式。血管性痴呆患者常表现出情绪和行为变化，在神经系统检查时可能有局灶性神经体征。主要治疗方法是通过对高血压等脑血管危险因素进行一级或二级干预，尽管使用胆碱酯酶抑制剂进行对症治疗已显示出一定程度的症状改善。
