Rahimy Mohamed Cherif, Fanou Lionnelle, Somasse Yassinme Elysee, Gangbo Annick, Ahouignan Gilbert, Alihonou Eusebe
National Sickle Cell Disease Center, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Republic of Benin, West Africa.
Pediatr Blood Cancer. 2007 May;48(5):544-9. doi: 10.1002/pbc.21103.
To study the efficacy of oral ferrous fumarate, an inexpensive, readily available preparation on iron deficiency in infants in Africa.
Four months old (group 1, n = 252) and 6-18 months old (group 2, n = 360) healthy infants attending four primary health care centers (PHC) for vaccination/well-child visits in Benin were studied. Ninety-six pregnant women (PW) over 36 weeks gestational age attending the same PHC during the study period were also studied. Infants were offered 2 months supplementation with oral powdered generic ferrous fumarate (GFF), that is, 5 mg/kg/day of elemental iron, given twice and were reevaluated 2 months later for hematological indices. The prevalence of anemia and iron deficiency among pregnant women was assessed using hematological indices and transferrin saturation.
The prevalence of anemia was 42.0%, 61.9%, and 37.5% in groups 1, 2, and PW, respectively. All anemic PW were iron deficient. Hemoglobin level shifted towards high values after supplementation. In addition, 24 infants from group 1 whose mothers interrupted the treatment, showed a significant decrease in hemoglobin level values, and similar improvement after two additional months of supplementation.
Programs to prevent iron deficiency in Africa should utilize inexpensive preparations, start during pregnancy, continue in infants at 3 months of age and address problems of noncompliance.
研究口服富马酸亚铁（一种廉价且易于获得的制剂）对非洲婴儿缺铁情况的疗效。
对在贝宁四个初级卫生保健中心（PHC）进行疫苗接种/健康儿童检查的4个月大（第1组，n = 252）和6 - 18个月大（第2组，n = 360）的健康婴儿进行了研究。还对在研究期间到同一初级卫生保健中心就诊的96名孕周超过36周的孕妇（PW）进行了研究。为婴儿提供为期2个月的口服普通富马酸亚铁粉剂（GFF）补充剂，即每天每千克体重5毫克元素铁，分两次服用，并在2个月后重新评估血液学指标。使用血液学指标和转铁蛋白饱和度评估孕妇贫血和缺铁的患病率。
第1组、第2组和孕妇组的贫血患病率分别为42.0%、61.9%和37.5%。所有贫血孕妇均缺铁。补充后血红蛋白水平向高值转变。此外，第1组中24名母亲中断治疗的婴儿，血红蛋白水平值显著下降，在额外补充两个月后有类似改善。
非洲预防缺铁的项目应使用廉价制剂，从孕期开始，在婴儿3个月大时继续进行，并解决不依从问题。
