Wang Chenguang, Guo Zheng, Li Xia, Yu Hui, Xu Jianzhen
Department of Bioinformatics, Harbin Medical University, Harbin 150086, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Dec;23(6):1157-61.
GeneHub software developed by us can be applied to evaluate the significance of expression similarity of genes in each functional unit of different gene function classification systems, and thus to select experiment condition related gene functional units. With different expression similarity measurement and different experiment data, we have applied GeneHub to analyze the expression correlation of functional related genes classified respectively with gene chromosome location, celluar location and interaction, metabolic pathway and signal transduction pathway relationship of protein products of genes. Genes classified according to these multiple ways all showed significant experimental condition related co-expression in our analysis. Our results provide further evidence for the assumption that functional related genes express similarly, which is widely adopted in gene expression profile analysis.
我们开发的GeneHub软件可用于评估不同基因功能分类系统中每个功能单元内基因表达相似性的显著性，从而筛选出与实验条件相关的基因功能单元。针对不同的表达相似性度量方法和不同的实验数据，我们运用GeneHub分别分析了按照基因染色体定位、细胞定位与相互作用、基因产物的代谢途径以及信号转导途径关系进行分类的功能相关基因的表达相关性。在我们的分析中，按照这些多种方式分类的基因均显示出与实验条件显著相关的共表达。我们的结果为“功能相关基因表达相似”这一假设提供了进一步的证据，该假设在基因表达谱分析中被广泛采用。
