Shah Jatin J, Meredith Ruby, Shen Sui, Nabors Burt, Lobuglio Albert, Yester Michael, Forero Andres
Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, AL, USA.
Clin Lymphoma Myeloma. 2006 Nov;7(3):236-8.
Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma arising within and confined to the central nervous system and, unlike other primary brain tumors, is very responsive to treatment. Aggressive management can lead to prolonged remissions or cures. However, the prognosis at relapse is generally poor with limited therapeutic options; clearly, new strategies are needed for these patients. Radioimmunotherapy has a growing role in the management of systemic non-Hodgkin lymphoma but has not been evaluated in PCNSL. We report here the first patient with PCNSL treated with radioimmunotherapy.
原发性中枢神经系统淋巴瘤（PCNSL）是一种罕见的非霍奇金淋巴瘤，起源于中枢神经系统并局限于该系统内，与其他原发性脑肿瘤不同，它对治疗反应非常敏感。积极的治疗可以延长缓解期或实现治愈。然而，复发时的预后通常较差，治疗选择有限；显然，这些患者需要新的治疗策略。放射免疫疗法在系统性非霍奇金淋巴瘤的治疗中发挥着越来越重要的作用，但尚未在PCNSL中进行评估。我们在此报告首例接受放射免疫疗法治疗的PCNSL患者。
