Risulo Massimiliano, Rubegni Pietro, Sbano Paolo, Sammassimo Simona, De Nisi Maria Caterina, Leoncini Lorenzo, Miracco Clelia, Fimiani Michele
Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy.
Clin Lymphoma Myeloma. 2006 Nov;7(3):239-41. doi: 10.3816/CLM.2006.n.065.
We report the case of a patient who presented with painful nodular subcutaneous lesions on the lower limbs and episodes of high temperature (> 39.5 degrees C). Histologic examination and immunohistochemical study of a biopsy specimen from a nodular lesion were consistent with the diagnosis of subcutaneous panniculitis-like T-cell lymphoma, a rare form of non-Hodgkin lymphoma. Diagnosis is made particularly difficult, especially in the early stages, by nonspecific clinical features shared by many types of panniculitis. Therefore, it seems advisable to consider the possibility of this type of lymphoma in all cases of panniculitis and to perform careful and continuous follow-up of all cases in which a clear diagnosis is not formulated at the outset, with regular repetition of skin biopsies at appropriate intervals.
我们报告了一例患者，其下肢出现疼痛性皮下结节性病变，并伴有高热（>39.5摄氏度）发作。对一个结节性病变的活检标本进行组织学检查和免疫组化研究，结果与皮下脂膜炎样T细胞淋巴瘤的诊断相符，皮下脂膜炎样T细胞淋巴瘤是一种罕见的非霍奇金淋巴瘤。由于多种类型脂膜炎具有非特异性临床特征，诊断尤为困难，尤其是在早期阶段。因此，对于所有脂膜炎病例，似乎都应考虑这种淋巴瘤的可能性，并对所有一开始未明确诊断的病例进行仔细且持续的随访，在适当间隔定期重复进行皮肤活检。
