卵巢神经内分泌癌，非小细胞型，伴浆液性癌。
Ovarian neuroendocrine carcinoma, non-small cell type, associated with serous carcinoma.
作者信息
Choi Yoo Duk, Lee Ji Shin, Choi Chan, Park Chang Soo, Nam Jong Hee
机构信息
Department of Pathology, Chonnam National University Medical School, 5 Hak-dong, Dong-gu, Gwangju, 501-749, Republic of Korea.
出版信息
Gynecol Oncol. 2007 Mar;104(3):747-52. doi: 10.1016/j.ygyno.2006.11.008. Epub 2007 Jan 16.
BACKGROUND
Neuroendocrine carcinoma of the non-small cell type of the ovary is a rare aggressive tumor, interestingly associated with either a surface epithelial tumor or teratoma.
CASE
A 71-year-old woman presented with a pelvic mass and underwent a total abdominal hysterectomy with a bilateral salpingo-oophorectomy. Pathology examination showed a 6.5 cm in greatest dimension ovarian tumor composed of neuroendocrine carcinoma of the non-small cell type and serous carcinoma. Immunohistochemical studies including keratin 7, WT-1, and neuroendocrine markers demonstrated differences in the two components. Microsatellite instability (MSI) analysis using five polymorphic markers also showed a different pattern in the two components.
CONCLUSION
This is the first report of an ovarian neuroendocrine carcinoma, non-small cell type, associated with a serous carcinoma. Immunohistochemistry and MSI are very helpful in making a definite diagnosis.
背景
卵巢非小细胞型神经内分泌癌是一种罕见的侵袭性肿瘤，有趣的是，它与表面上皮性肿瘤或畸胎瘤有关。
病例
一名71岁女性因盆腔肿块就诊，接受了全腹子宫切除术及双侧输卵管卵巢切除术。病理检查显示一个最大径为6.5 cm的卵巢肿瘤，由非小细胞型神经内分泌癌和浆液性癌组成。包括角蛋白7、WT-1和神经内分泌标志物在内的免疫组织化学研究显示这两种成分存在差异。使用五个多态性标记进行的微卫星不稳定性（MSI）分析也显示这两种成分呈现不同模式。
结论
这是首例关于卵巢非小细胞型神经内分泌癌合并浆液性癌的报道。免疫组织化学和MSI对明确诊断非常有帮助。
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