Sambeth Anke, Blokland Arjan, Harmer Catherine J, Kilkens Tessa O C, Nathan Pradeep J, Porter Richard J, Schmitt Jeroen A J, Scholtissen Bart, Sobczak Sjacko, Young Allan H, Riedel Wim J
Department of Neurocognition, Faculty of Psychology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Neurosci Biobehav Rev. 2007;31(4):516-29. doi: 10.1016/j.neubiorev.2006.11.009. Epub 2007 Jan 16.
Acute tryptophan depletion (ATD) studies have shown that serotonin plays a role in learning and memory processes. In this study, we performed a pooled analysis of nine ATD studies in order to examine the nature of the memory-impairing effects of ATD and mediating factors, such as gender, age and vulnerability for disease in which disturbed serotonin was hypothesized to play a role. All studies that were used in this pooled analysis assessed declarative episodic memory using a verbal learning task paradigm. Immediate recall, delayed recall, and delayed recognition scores were examined. A total of 211 participants were included in the analysis. The analysis revealed that ATD impaired not only delayed recall, but also immediate recall. The ATD-induced impairments were larger in females than in males. Furthermore, ATD did not interact with any other serotonergic vulnerability and age. This suggests that the only factor that actually has the properties of a serotonergic vulnerability factor for declarative memory performance is female gender. The findings provide further support for a critical role of serotonin in declarative episodic memory.
急性色氨酸耗竭（ATD）研究表明，血清素在学习和记忆过程中发挥作用。在本研究中，我们对9项ATD研究进行了汇总分析，以检验ATD记忆损害效应的本质以及中介因素，如性别、年龄和疾病易感性，其中假设血清素紊乱在这些因素中发挥作用。本汇总分析中使用的所有研究均采用言语学习任务范式评估陈述性情景记忆。对即时回忆、延迟回忆和延迟识别分数进行了检查。共有211名参与者纳入分析。分析显示，ATD不仅损害延迟回忆，还损害即时回忆。ATD诱导的损害在女性中比在男性中更大。此外，ATD与任何其他血清素能易感性和年龄均无相互作用。这表明，实际上对陈述性记忆表现具有血清素能易感性因素特征的唯一因素是女性性别。这些发现为血清素在陈述性情景记忆中的关键作用提供了进一步支持。
