Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Acta Psychiatr Scand. 2013 Aug;128(2):133-41. doi: 10.1111/acps.12089. Epub 2013 Feb 19.
Animal experiments and studies in adults have shown that the neurotransmitter serotonin (5-HT) plays an important role in learning and memory processes. However, data on this relationship in young persons are scarce, and neurodietary research in this age group is limited compared with the extensive literature on adults. Here, we aimed to explore the effects of a diminished central nervous 5-HT synthesis, which is achieved by acute tryptophan depletion (ATD) Moja-De , on memory function in young males with attention deficit hyperactivity disorder (ADHD).
Twenty-two male patients with ADHD (ages 9-15 years, mean 10.95 ± 1.17 years) received ATD, thus diminishing central nervous 5-HT synthesis, and a tryptophan-balanced amino acid load (BAL) in a randomized, double-blind, within-subject, crossover design study. Approximately 1.7 h after administration of ATD/BAL, verbal declarative memory was assessed using the 'Auditory Verbal-Learning-Test' (AVLT).
There were no significant effects of ATD administration on verbal declarative memory function.
In this study, changes in 5-HT neurotransmission were not associated with specific aspects of verbal declarative memory in young persons with ADHD. Future studies with healthy control groups that address effects of covarying attentional processes are warranted.
动物实验和成人研究表明，神经递质 5-羟色胺（5-HT）在学习和记忆过程中起着重要作用。然而，关于年轻人的这种关系的数据很少，与关于成年人的广泛文献相比，该年龄组的神经饮食研究有限。在这里，我们旨在探讨通过急性色氨酸耗竭（ATD）降低中枢神经系统 5-HT 合成对注意力缺陷多动障碍（ADHD）年轻男性记忆功能的影响。
22 名患有 ADHD 的男性患者（年龄 9-15 岁，平均 10.95 ± 1.17 岁）接受 ATD，从而降低中枢神经系统 5-HT 合成，并接受随机、双盲、自身对照、交叉设计研究中的色氨酸平衡氨基酸负荷（BAL）。在 ATD/BAL 给药后约 1.7 小时，使用“听觉言语学习测试”（AVLT）评估言语陈述性记忆。
ATD 给药对言语陈述性记忆功能没有显著影响。
在这项研究中，5-HT 神经递质传递的变化与 ADHD 年轻患者言语陈述性记忆的特定方面无关。未来需要与健康对照组进行研究，以解决注意力过程的影响。
