Werner-Felmayer G, Werner E R, Fuchs D, Hausen A, Reibnegger G, Wachter H
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
Adv Exp Med Biol. 1991;294:505-9. doi: 10.1007/978-1-4684-5952-4_55.
IFN-gamma is the most effective principle responsible for IDO induction in human cells in vitro. Lymphocyte factors support the effect of other IFN species. Induction of IDO and influence of various factors on IDO is correlated to pteridine synthesis. Cooperative effects of several mediators may account for in vivo observations concerning enhanced excretion of neopterin and tryptophan metabolites in certain disease states.
γ干扰素是体外诱导人细胞中吲哚胺2,3-双加氧酶（IDO）的最有效因子。淋巴细胞因子可增强其他干扰素的作用。IDO的诱导以及各种因素对IDO的影响与蝶啶合成相关。几种介质的协同作用可能解释了在某些疾病状态下新蝶呤和色氨酸代谢产物排泄增加的体内观察结果。
