Krzemiński K, Mikulski T, Nazar K
Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
J Physiol Pharmacol. 2006 Dec;57(4):571-81.
The aim of the study was to find out whether prolonged exercise influences plasma adrenomedullin (ADM) concentration and whether it is related to the hormonal, metabolic and cardiovascular changes. Eighteen healthy subjects (age 25+/-1 yrs) were submitted to cycle exercise for 90 min at 70% of maximal oxygen uptake. Heart rate (HR) and blood pressure (BP) were measured continously. Before, at 30(th) min, and at the end of exercise venous blood samples were taken for [ADM], noradrenaline [NA], adrenaline [A], atrial natriuretic peptide [ANP], plasma renin activity PRA, interleukin-6 [IL-6] and lactate [LA] determination. Significant increases in plasma ADM and IL-6 were found at 90(th) min whereas other hormones were elevated already at 30(th) min of exercise. Positive correlations were ascertained between [ADM] and [NA] (r=0.47), [ANP] (r=0.35) or [IL-6] (r=0.35) and between exercise-induced increases in [ADM] and [NA] (r=0.38). PRA correlated positively with [NA] and [ANP]. Negative correlation was found between plasma [ADM] and diastolic BP. The present data suggest that increase in sympathetic nervous activity and cytokine induction during prolonged exercise may be involved in plasma ADM release and that increase in ADM and ANP secretion may be a compensatory mechanism against further elevation of blood pressure.
本研究的目的是探究长时间运动是否会影响血浆肾上腺髓质素（ADM）浓度，以及它是否与激素、代谢和心血管变化有关。18名健康受试者（年龄25±1岁）在最大摄氧量的70%下进行了90分钟的自行车运动。连续测量心率（HR）和血压（BP）。在运动前、第30分钟和运动结束时采集静脉血样，用于测定[ADM]、去甲肾上腺素[NA]、肾上腺素[A]、心钠素[ANP]、血浆肾素活性PRA、白细胞介素-6[IL-6]和乳酸[LA]。在第90分钟时发现血浆ADM和IL-6显著增加，而其他激素在运动第30分钟时就已升高。[ADM]与[NA]（r=0.47）、[ANP]（r=0.35）或[IL-6]（r=0.35）之间以及运动诱导的[ADM]和[NA]增加之间（r=0.38）确定存在正相关。PRA与[NA]和[ANP]呈正相关。血浆[ADM]与舒张压呈负相关。目前的数据表明，长时间运动期间交感神经活动的增加和细胞因子的诱导可能参与血浆ADM的释放，并且ADM和ANP分泌的增加可能是一种对抗血压进一步升高的代偿机制。
