Khouri R K, Brown D M, Leal-Khouri S M, Tark K C, Shaw W W
Institute of Reconstructive Plastic Surgery, New York University Medical Centre, New York.
Br J Plast Surg. 1991 Nov-Dec;44(8):585-8. doi: 10.1016/0007-1226(91)90094-z.
Forty-two male Sprague-Dawley rats were utilised to determine whether the angiogenic property of basic fibroblast growth factor (bFGF) could be applied to improve the survival of the ischaemic portion of a random skin flap and to accelerate the process of staged flap transfer. In the ischaemic flap model, bFGF enhanced the development of vascular connections between the bed and the flap and prevented marginally perfused areas from undergoing necrosis. No effect was observed in the staged reconstruction model using the same dosage of bFGF. A speculative explanation is given for the differential effect of BFGF in these two models. The application of angiogenic factors may improve the survival of the random portion of skin flaps. Further investigations are needed to determine whether exogenously applied angiogenic factors can have a beneficial effect in staged flap reconstructions.
使用42只雄性Sprague-Dawley大鼠来确定碱性成纤维细胞生长因子（bFGF）的血管生成特性是否可用于提高随意皮瓣缺血部分的存活率，并加速分期皮瓣转移的过程。在缺血皮瓣模型中，bFGF促进了皮瓣床与皮瓣之间血管连接的形成，并防止了灌注不良区域发生坏死。在使用相同剂量bFGF的分期重建模型中未观察到效果。对bFGF在这两种模型中的不同作用给出了一种推测性解释。血管生成因子的应用可能会提高随意皮瓣部分的存活率。需要进一步研究以确定外源性应用血管生成因子在分期皮瓣重建中是否能产生有益效果。
