Takato T, Zuker R M, Turley C B
Division of Plastic Surgery, Hospital for Sick Children, Toronto, Canada.
Br J Plast Surg. 1991 Nov-Dec;44(8):593-8. doi: 10.1016/0007-1226(91)90096-3.
Prefabrication provides a new method for creating donor sites which are not limited by natural vascular territories. There are several methods for prefabrication, and these include implantation of greater omentum, blood vessels or muscle flaps. Based on the concept that an arterio-venous (A-V) shunt results in sufficient neovascularisation to support a free flap, we used a rabbit model to investigate the characteristics of these flaps. Prefabrication of an abdominal wall donor site was performed using the left epigastric vein in 20 male New Zealand white rabbits. An 8 x 10 cm skin flap was elevated 10 days after prefabrication, either as an island or a free flap. Survival of the skin flaps exceeded 93% and was independent of position of the vascular pedicle, direction of blood flow, or nature of the flap (island or free flap). Angiograms showed a very rich neovascularisation within the prefabricated flap.
预制技术为创建不受天然血管区域限制的供区提供了一种新方法。预制有多种方法，包括大网膜、血管或肌皮瓣植入。基于动静脉（A-V）分流可导致足够的新生血管形成以支持游离皮瓣的概念，我们使用兔模型来研究这些皮瓣的特性。在20只雄性新西兰白兔中，利用左腹壁静脉对腹壁供区进行预制。预制10天后掀起一个8×10 cm的皮瓣，可为岛状皮瓣或游离皮瓣。皮瓣存活率超过93%，且与血管蒂位置、血流方向或皮瓣性质（岛状或游离皮瓣）无关。血管造影显示预制皮瓣内新生血管非常丰富。
