Morrison W A, Dvir E, Doi K, Hurley J V, Hickey M J, O'Brien B M
Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Australia.
Br J Plast Surg. 1990 Nov;43(6):645-54. doi: 10.1016/0007-1226(90)90184-2.
The arteriovenous pedicle of all known axial-pattern skin flaps enters from the deep aspect and consequently the flap must contain fat and/or muscle and be of considerable thickness. In an attempt to fabricate a thinner axial-pattern flap the femoral artery and vein of rabbits were implanted, in various vascular configurations, directly into the subdermal layer of the skin. Implantation was found to provoke an extensive outgrowth of new vessels from the implanted artery and vein, and the progress and pattern of this neovascularisation was studied by carbon gelatine perfusion and histology. Neovascularisation begins within a few days of implantation and progresses rapidly. By 8 to 12 weeks it is possible to elevate regularly a viable, large skin flap based on the implanted pedicle.
所有已知轴型皮瓣的动静脉蒂都从深部进入，因此皮瓣必须包含脂肪和/或肌肉，且厚度可观。为了制作更薄的轴型皮瓣，将兔的股动脉和静脉以各种血管构型直接植入皮肤的皮下层。发现植入会引发植入的动脉和静脉大量长出新血管，并通过碳明胶灌注和组织学研究了这种新生血管形成的过程和模式。新生血管形成在植入后几天内开始，并迅速进展。到8至12周时，可以定期掀起一个基于植入蒂的存活大皮瓣。
