Klöppel M, Tudor C, Kovacs L, Papadopulos N A, Höhnke C, Himsl I, Hoang N T, Biemer E
Department of Plastic and Reconstructive Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
J Reconstr Microsurg. 2007 Jan;23(1):45-9. doi: 10.1055/s-2006-958702.
In this experimental study on 96 CD rats, microvascular end-to-end anastomoses created via suture or alternatively by means of a VCS-Clip-Application-System, were compared. The aorta abdominalis of the animals, with a diameter of 1.5 +/- 0.2 mm, was experimentally dissected, and the free ends of the vessel then anastomosed. The results were evaluated using sonography, microangiography, histologic examination, and vascular imprints. Postoperative examination was carried out after 1, 3, 7, 14, or 30 days. Major advantages of the VCS-Clip technique over suturing were that it was easy to learn, significantly faster to perform (execution of anastomosis 10.9 +/- 2.6 min versus 19.4 +/- 5.0 min), and produced significantly more favorable histologic results in terms of less inflammatory response, foreign body reaction, necrosis of the tunica media, hyperplasia of the intima, and thrombosis of the vessel lumen. The main disadvantage of the clip technique was a significantly higher rate of stenoses (15.8 +/- 6.0 versus 4.1 +/- 6.6 percent).
在这项针对96只CD大鼠的实验研究中，对通过缝合或使用VCS夹应用系统进行的微血管端端吻合术进行了比较。实验解剖了直径为1.5±0.2毫米的动物腹主动脉，然后将血管的游离端进行吻合。使用超声检查、微血管造影、组织学检查和血管印记对结果进行评估。术后在1、3、7、14或30天进行检查。VCS夹技术相对于缝合的主要优点是易于学习，操作速度明显更快（吻合术执行时间为10.9±2.6分钟，而缝合为19.4±5.0分钟），并且在炎症反应、异物反应、中膜坏死、内膜增生和血管腔血栓形成方面产生了明显更有利的组织学结果。夹技术的主要缺点是狭窄率明显更高（15.8±6.0%对4.1±6.6%）。
