HeLa cells apoptosis induced by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane.
作者信息
Yang Li, Liang Feng, Liu Min, Zheng Congyi, Wan Shuhui, Xiong Xiaoqin, Zhang Xiaolian, Shen Chao, Zhou Xiang
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
出版信息
Bioorg Med Chem Lett. 2007 Mar 15;17(6):1818-22. doi: 10.1016/j.bmcl.2006.12.036. Epub 2006 Dec 15.
PMID:17234411
Abstract
Preliminary pharmacological tests showed that 1,7-dimethyl-1,4,7,10-tetraazacyclododecane (DMC) had antitumor activity against HeLa and A549 cell lines in vitro. The HeLa cells apoptosis induced by DMC was examined by flow cytometric meter, and further confirmed by observing the morphological changes and DNA fragmentation. No observation of A549 cells induced apoptosis was observed by DMC.
摘要
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