Combination of porphyrins and DNA-alkylation agents: synthesis and tumor cell apoptosis induction.
作者信息
He Hanping, Zhou Yan, Liang Feng, Li Dongqing, Wu Juanjuan, Yang Li, Zhou Xiang, Zhang Xiaolian, Cao Xiaoping
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, PR China.
出版信息
Bioorg Med Chem. 2006 Feb 15;14(4):1068-77. doi: 10.1016/j.bmc.2005.09.041. Epub 2005 Nov 11.
PMID:16289853
Abstract
A series of porphyrin-DNA cross-linking conjugates were synthesized. Their cytotoxicities to tumor cells were tested using MTT assays first. Then, HeLa cell apoptosis induced by these cationic porphyrins under the light was examined by laser confocal microscopy, flow cytometric analysis, and further confirmed by observing the morphological changes and DNA fragmentation mainly.
摘要
Zotero 插件