Nayler W G, Britnell S
Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
J Cardiovasc Pharmacol. 1991;18 Suppl 1:S1-5.
The tissue-protective effect of the calcium antagonists is a complex phenomenon that needs to be considered at the cellular as well as the organ level, and with respect to both the vasculature and myocardium. As far as the vasculature and the myocardium are concerned, hypertension is a major risk factor. The dihydropyridine-based calcium antagonists are protective under these circumstances, not only because of their blood pressure-lowering effect but also because of their ability to slow plaque formation and possibly to provide some protection against oxyradical-induced injury. With regard to the myocardium, tissue protection in the presence of hypertension involves not only a reduction in hypertrophy, but also a reduction in ischemia-induced injury and the incidence of damage due to lipid peroxidation.
钙拮抗剂的组织保护作用是一个复杂的现象，需要在细胞和器官水平上，以及在血管系统和心肌方面加以考虑。就血管系统和心肌而言，高血压是一个主要危险因素。在这些情况下，基于二氢吡啶的钙拮抗剂具有保护作用，这不仅是因为它们的降压作用，还因为它们能够减缓斑块形成，并可能提供一些针对氧自由基诱导损伤的保护。关于心肌，高血压情况下的组织保护不仅涉及减轻心肌肥厚，还涉及减少缺血诱导的损伤以及脂质过氧化导致的损伤发生率。
