Michel D
Fortschr Med. 1991 Feb 20;109(5):125-8.
Irrespective of the presence of hypertension, left ventricular hypertrophy, a cardiovascular risk factor in its own right, increases cardiac morbidity and mortality. In addition to ventricular hypertrophy, arteriole wall hypertrophy and its effects on endogenous vessel wall function are also important factors, in particular in hypertension. Calcium is involved in this process, the elevation of free intracellular calcium probably being of greater importance than calcium entering the cells via channels. Thus, effective drug-induced organ protection requires that the substance employed as an anti-hypertensive should lower blood pressure, reduce left-ventricular hypertrophy, and inhibit vascular changes. Animal experiments have shown that calcium antagonists meet these requirements.
无论是否存在高血压，左心室肥厚本身就是一种心血管危险因素，会增加心脏发病率和死亡率。除心室肥厚外，小动脉壁肥厚及其对内源性血管壁功能的影响也是重要因素，尤其是在高血压患者中。钙参与了这一过程，细胞内游离钙的升高可能比通过通道进入细胞的钙更为重要。因此，有效的药物诱导器官保护要求用作抗高血压的物质应降低血压、减轻左心室肥厚并抑制血管变化。动物实验表明钙拮抗剂符合这些要求。
