Luna Augustin, Nicodemus Kristin K
GCAP/CBDB, NIMH/NIH, 10 Center Drive, Room 4S-235, Bethesda, MD 20814, USA.
Bioinformatics. 2007 Mar 15;23(6):774-6. doi: 10.1093/bioinformatics/btl657. Epub 2007 Jan 18.
snp.plotter is a newly developed R package which produces high-quality plots of results from genetic association studies. The main features of the package include options to display a linkage disequilibrium (LD) plot below the P-value plot using either the r2 or D' LD metric, to set the X-axis to equal spacing or to use the physical map of markers, and to specify plot labels, colors, symbols and LD heatmap color scheme. snp.plotter can plot single SNP and/or haplotype data and simultaneously plot multiple sets of results. R is a free software environment for statistical computing and graphics available for most platforms. The proposed package provides a simple way to convey both association and LD information in a single appealing graphic for genetic association studies.
Downloadable R package and example datasets are available at http://cbdb.nimh.nih.gov/~kristin/snp.plotter.html and http://www.r-project.org.
snp.plotter是一个新开发的R包,可生成遗传关联研究结果的高质量图表。该包的主要功能包括使用r2或D'连锁不平衡(LD)度量在P值图下方显示LD图的选项,将X轴设置为等间距或使用标记的物理图谱,以及指定图表标签、颜色、符号和LD热图配色方案。snp.plotter可以绘制单个单核苷酸多态性(SNP)和/或单倍型数据,并同时绘制多组结果。R是一个免费的统计计算和图形软件环境,大多数平台均可使用。该提议的包为在遗传关联研究的单个吸引人的图形中传达关联和LD信息提供了一种简单方法。
可在http://cbdb.nimh.nih.gov/~kristin/snp.plotter.html和http://www.r-project.org下载R包和示例数据集。