Webb Emily L, Sellick Gabrielle S, Houlston Richard S
Section of Cancer Genetics, Institute of Cancer Research 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Bioinformatics. 2005 Jul 1;21(13):3060-1. doi: 10.1093/bioinformatics/bti449. Epub 2005 Apr 19.
SNPLINK is a Perl script that performs full genome linkage analysis of high-density single nucleotide polymorphism (SNP) marker sets. The presence of linkage disequilibrium (LD) between closely spaced SNP markers can falsely inflate linkage statistics. SNPLINK removes LD from the marker sets in an automated fashion before carrying out linkage analysis. SNPLINK can compute both parametric and non-parametric statistics, utilizing the freely available Allegro and Merlin software. Graphical outputs of whole genome multipoint linkage statistics are provided allowing comparison of results before and after the removal of LD.
SNPLINK是一个Perl脚本，用于对高密度单核苷酸多态性（SNP）标记集进行全基因组连锁分析。紧密间隔的SNP标记之间存在连锁不平衡（LD），可能会错误地夸大连锁统计量。在进行连锁分析之前，SNPLINK会以自动化方式从标记集中去除LD。SNPLINK可以利用免费的Allegro和Merlin软件计算参数统计量和非参数统计量。提供全基因组多点连锁统计的图形输出，以便比较去除LD前后的结果。
