Jiang H, Takahara S, Kyo M, Kokado Y, Ishibashi M, Sonoda T
Department of Urology, Osaka University Hospital, Japan.
Eur Surg Res. 1991;23(3-4):201-5. doi: 10.1159/000129153.
The effect of FK-506 on allograft survival in unsensitized recipients has been established in several animal experimental models. In this present study, we investigated the immunosuppressive capacity of FK-506, in comparison with ciclosporin (Cs) and 15-deoxyspergualin (DSG), on heart allograft in presensitized rats. Heart grafts from male ACI rats were heterotopically transplanted to male LEW rats. All recipient rats were sensitized with donor-type whole blood admixed with immunoadjuvant (adjuvant complete Freund) 7 days prior to transplantation. FK-506, Cs and DSG were administered from day 0 to day 14 posttransplantation. The results showed that both FK-506 and Cs significantly prolonged heart allograft survival of presensitized recipients in a dose-dependent manner. The minimum effective dose in the treatment was less for FK-506 than for Cs. However, DSG showed almost no effect of prolongation in this experiment.
FK-506对未致敏受体同种异体移植物存活的影响已在多个动物实验模型中得到证实。在本研究中，我们将FK-506与环孢素（Cs）和15-去氧精胍菌素（DSG）进行比较，研究了其对致敏大鼠心脏同种异体移植物的免疫抑制能力。将雄性ACI大鼠的心脏移植物异位移植到雄性LEW大鼠体内。所有受体大鼠在移植前7天用与免疫佐剂（完全弗氏佐剂）混合的供体类型全血进行致敏。FK-506、Cs和DSG在移植后第0天至第14天给药。结果表明，FK-506和Cs均以剂量依赖方式显著延长了致敏受体的心脏同种异体移植物存活时间。治疗中的最小有效剂量FK-506比Cs小。然而，在本实验中DSG几乎没有显示出延长作用。
