Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, USA.
Transplant Rev (Orlando). 2012 Jul;26(3):189-200. doi: 10.1016/j.trre.2011.07.005. Epub 2011 Nov 8.
Nuclear factor (NF) κB is a pleiotropic transcription factor that is ubiquitously expressed. After transplantation of solid organs, NF-κB in the graft is activated within a few hours as a consequence of ischemia/reperfusion and then again after a few days in intragraft infiltrating cells during the process of acute allograft rejection. In the present article, we review the components of the NF-κB pathway, their mechanisms of activation, and their role in T cell and antigen-presenting cell activation and differentiation and in solid organ allograft rejection. Targeted inhibition of NF-κB in selected cell types may promote graft survival with fewer adverse effects compared with global immunosuppressive therapies.
核因子 (NF) κB 是一种普遍表达的多功能转录因子。在实体器官移植后，由于缺血/再灌注，移植物中的 NF-κB 在数小时内被激活，然后在急性同种异体移植排斥过程中，移植物内浸润细胞中数天后再次被激活。在本文中，我们综述了 NF-κB 通路的组成部分、它们的激活机制，以及它们在 T 细胞和抗原呈递细胞激活和分化以及实体器官同种异体移植排斥中的作用。与全身性免疫抑制治疗相比，针对特定细胞类型的 NF-κB 抑制可能会促进移植物存活，且不良反应更少。
