Chang Hong, Schimmer Aaron D
Princess Margaret Hospital, Room 9-516, 610 University Avenue, Toronto, Ontario, Canada.
Mol Cancer Ther. 2007 Jan;6(1):24-30. doi: 10.1158/1535-7163.MCT-06-0443.
Livin, also called melanoma inhibitor of apoptosis protein (IAP) or kidney IAP, is a member of the IAP family of caspase inhibitors that selectively binds the endogenous IAP antagonist SMAC and caspase-3, caspase-7, and caspase-9. As such, Livin inhibits apoptosis, and its overexpression renders malignant cells resistant to chemotherapy. Therefore, inhibitors of Livin could be useful adjuncts to chemotherapy in the treatment of malignancies. This review will discuss Livin as a potential therapeutic target and strategies for its inhibition, including antisense oligonucleotides, small-molecule inhibitors, and immune-mediated approaches.
生存素，也称为黑色素瘤凋亡抑制蛋白（IAP）或肾IAP，是半胱天冬酶抑制蛋白IAP家族的成员，它能选择性地结合内源性IAP拮抗剂SMAC以及半胱天冬酶-3、半胱天冬酶-7和半胱天冬酶-9。因此，生存素可抑制细胞凋亡，其过表达使恶性细胞对化疗产生抗性。所以，生存素抑制剂可能是治疗恶性肿瘤化疗中的有用辅助药物。本综述将讨论生存素作为潜在治疗靶点及其抑制策略，包括反义寡核苷酸、小分子抑制剂和免疫介导方法。
