[成人肾母细胞瘤]

[Wilms' tumors in adults].

作者信息

Zugor V, Krot D, Kühn R, Schrott K M, Schott G E

机构信息

Urologische Klinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen.

出版信息

Urologe A. 2007 Apr;46(4):402, 404-5. doi: 10.1007/s00120-006-1286-1.

DOI:10.1007/s00120-006-1286-1

PMID:17237959

Abstract

Wilms' tumors develop from persistent, primitive metanephrogenic stem cells. Their biology and etiology in adults is still unknown even though remnants of primitive metanephrogenic tissue, which tends to malignancy, is suspected, and there are very few scientific studies on the biology of Wilms' tumors in adults. Such a tumor occurs at a rate of 0.2/million adults in Europe and the USA. In this article, we describe the course of the disease in two adults with histologically confirmed Wilms' tumors. Both patients underwent a radical nephrectomy followed by chemotherapy as indicated by the SIOP nephroblastoma study.

摘要

肾母细胞瘤由持续存在的原始后肾源性干细胞发展而来。尽管怀疑存在有恶变倾向的原始后肾组织残余，但成人肾母细胞瘤的生物学特性和病因仍不清楚，而且关于成人肾母细胞瘤生物学特性的科学研究非常少。在欧洲和美国，这种肿瘤在成人中的发病率为每百万成人中有0.2例。在本文中，我们描述了两名经组织学确诊为肾母细胞瘤的成人患者的疾病过程。两名患者均接受了根治性肾切除术，随后根据国际小儿肿瘤学会（SIOP）肾母细胞瘤研究的指征进行了化疗。