[针对委内瑞拉马脑炎病毒的单克隆抗体的生物学和免疫化学特性]
[The biological and immunochemical properties of monoclonal antibodies to the Venezuelan equine encephalomyelitis virus].
作者信息
Shpilevaia M V, Tugizov Sh M, Kushch A A, Tsilinskiĭ Ia Ia, Makarova N E
出版信息
Vopr Virusol. 1991 Nov-Dec;36(6):495-8.
PMID:1723821
Abstract
Five strains of hybrid cells producing highly active monoclonal antibodies (MCA) to Venezuelan equine encephalomyelitis (VEE) virus were generated. VEEC6 MCA had high virus-neutralizing and hemagglutinating activities attesting to their direction to the "critical" site of E2 glycoprotein. MCA VEEA5 directed to the same glycoprotein did not overlap spatially with the previous one. MCA VEEB5 and VEEA4 interacted with conformational virus determinants taking part in hemagglutination.
摘要
产生针对委内瑞拉马脑炎（VEE）病毒的高活性单克隆抗体（MCA）的五株杂交细胞被培育出来。VEEC6 MCA具有高病毒中和活性和血凝活性，证明它们针对E2糖蛋白的“关键”位点。针对同一糖蛋白的MCA VEEA5在空间上与前者不重叠。MCA VEEB5和VEEA4与参与血凝的构象病毒决定簇相互作用。
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