UytdeHaag F, van der Heijden R, Osterhaus A
Laboratory of Immunobiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Immunol Today. 1991 Dec;12(12):439-42. doi: 10.1016/0167-5699(91)90016-m.
How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrogate antigen, selecting and stimulating emerging antigen-specific lymphocytes.
记忆是如何保留的是一个免疫学之谜。方斯·于伊特德哈格及其同事在此提出的一种可能性是，记忆被印记在某些CD5 + B细胞所表达的经体细胞突变的免疫球蛋白（Ig）中。该理论提出，由这群自我更新的细胞所表达的Ig充当替代抗原，选择并刺激新出现的抗原特异性淋巴细胞。
