Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), AP 70228, Ciudad Universitaria, México, DF 04510, Mexico.
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), AP 70228, Ciudad Universitaria, México, DF 04510, Mexico.
Cell Immunol. 2020 Dec;358:104235. doi: 10.1016/j.cellimm.2020.104235. Epub 2020 Oct 11.
Antibodies, T cell receptors and major histocompatibility complex molecules are members of the immunoglobulin superfamily and have pivotal roles in the immune system. The fine interrelation between them regulates several immune functions. Here, we describe lesser-known functions ascribed to these molecules in generating and maintaining immune response. Particularly, we outline the contribution of antibody- and T cell receptor-derived complementarity-determining region neoantigens, antigenized antibodies, as well as major histocompatibility complex class I molecules-derived epitopes to the induction of protective/therapeutic immune responses against pathogens and cancer. We discuss findings of our own and other studies describing protective mechanisms, based on immunogenic properties of immunoglobulin superfamily members, and evaluate the perspectives of application of this class of immunogens in molecular vaccines design.
抗体、T 细胞受体和主要组织相容性复合体分子是免疫球蛋白超家族的成员，在免疫系统中起着关键作用。它们之间的精细相互关系调节着几种免疫功能。在这里，我们描述了这些分子在产生和维持免疫反应方面的一些鲜为人知的功能。特别是，我们概述了抗体和 T 细胞受体衍生的互补决定区新抗原、抗原化抗体以及主要组织相容性复合体 I 类分子衍生的表位对诱导针对病原体和癌症的保护性/治疗性免疫反应的贡献。我们讨论了自己和其他研究的发现，这些研究描述了基于免疫球蛋白超家族成员免疫原性的保护性机制，并评估了这一类免疫原在分子疫苗设计中的应用前景。
