Störk Stefan, Bots Michiel L, Angerer Peter, von Schacky Clemens, Grobbee Diederick E, Angermann Christiane E, Seufert Jochen
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
Atherosclerosis. 2007 Oct;194(2):e147-53. doi: 10.1016/j.atherosclerosis.2006.11.044. Epub 2007 Jan 19.
Adipocytokines are under investigation as mediators of cardiovascular risk. In 142 non-diabetic postmenopausal women, we investigated whether plasma levels of adiponectin and leptin are associated with changes in carotid intima-media thickness (IMT) and distensibility as assessed by high-resolution ultrasound. Adiponectin but not leptin correlated weakly with baseline measures of IMT and distensibility. After 12 months, carotid IMT showed a significant progression [0.023 mm (95% CI, 0.014-0.031 mm)] whereas stiffness was unaltered. A threshold was identified for the relation of adiponectin with both progression of IMT and stiffness. Age-adjusted adiponectin levels in the lowest quartile versus second to fourth quartile were related to progression of IMT (odds ratio, 2.99; 95% CI, 1.81-5.09) and stiffness (odds ratio, 1.71; 95% CI, 1.19-4.07). Adjustment for possible confounding factors and intermediates weakened this association only to a minor degree. No such associations were observed for leptin. We conclude that low levels of adiponectin are associated with adverse changes in morphology and function of central arteries over time independently of other cardiovascular risk factors in postmenopausal non-diabetic women.
脂肪细胞因子作为心血管风险的介质正在接受研究。在142名非糖尿病绝经后女性中，我们研究了脂联素和瘦素的血浆水平是否与通过高分辨率超声评估的颈动脉内膜中层厚度（IMT）和扩张性变化相关。脂联素而非瘦素与IMT和扩张性的基线测量值呈弱相关。12个月后，颈动脉IMT显示出显著进展[0.023毫米（95%可信区间，0.014 - 0.031毫米）]，而僵硬度未改变。确定了脂联素与IMT进展和僵硬度之间关系的一个阈值。最低四分位数与第二至第四四分位数的年龄调整后脂联素水平与IMT进展（优势比，2.99；95%可信区间，1.81 - 5.09）和僵硬度（优势比，1.71；95%可信区间，1.19 - 4.07）相关。对可能的混杂因素和中间变量进行调整只会轻微削弱这种关联。瘦素未观察到此类关联。我们得出结论，在绝经后非糖尿病女性中，低水平的脂联素与随着时间推移中央动脉形态和功能的不良变化相关，且独立于其他心血管风险因素。
